Molecular Analysis/Mass Spectrometry - Equipment

Q-qTOF impact HD (Bruker) with Dionex3000 Nano-UPLC (Thermo Dionex)

The main applications of the instrument system are

  • Quantitative Proteomics
  • (Quantitative) Analysis of Protein Post-translational Modifications
  • Functional Proteomics (Co-IPs)
  • Determination of Intact Protein Mass

LTQ-Orbitrap XL ETD (Thermo Scientific) with Dionex3000 Nano-HPLC (Thermo Dionex)

The main applications of the instrument system are

  • Analysis of Protein Post-translational Modifications
  • (Quantitative) Proteomics
  • Functional Proteomics (Co-IPs)

This MS provides three different fragmentation modes (CID, HCD, ETD); A combination that is benefical for the detailed characterization of PTMs.

amaZon Speed ETD Iontrap (Bruker) with Dionex3000 Micro-HPLC (Thermo Dionex)

The main applications of the instrument system are

  • Qualitative Protein Analysis (QC)
  • Peptide Characterization


  • Small Molecule Characterization

This MS provides 2 different fragmentation modes (CID, ETD) helpful for structural analysis.

Octet Biosensor (Fort├ęBio)

This device provides real-time, label-free analysis for determination of affinity, kinetics and concentration of biomolecules, including but not limited to antibody-antigen interaction. Kinetic analysis including association and dissociation of biomolecules can be performed on up to 384 samples in one 384-well microplate.

  • High sensitivity detection
  • 16-well simultaneous sampling
  • 384-well and 96-well formats
  • Two plate locations maximize throughput and improve workflow
  • Automation friendliness allows multiple-plate assays in one run
  • Biosensor re-racking allows maximum flexibility and operational cost savings
  • Advanced software offers greater versatility in experimental design and data analysis

CD spectroscope (Chirascan-Plus, Applied Photophysics)

This device provides Circular Dichroism (CD) spectroscopy as a fast and sensitive tool for probing secondary structure of biomolecules (peptides, proteins, DNA, RNA). It is particularly powerful in observing changes of secondary structure with environmental conditions (e.g. temperature, pH, salt), upon mutation or on interaction with other molecules yielding structural, kinetic and thermodynamic information.

  • The instrument offers exceptionally high sensitivity and unparalleled far-UV performance for fast CD measurement
  • Quick assessment of protein structure to determine whether an expressed/purified protein is folded
  • Thermal stability measurements with temperature ramping experiment
  • Simultaneous circular dichroism, absorption and fluorescence detection
  • Easy and rapid evaluation of spectra and calculation of protein secondary structure content